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Why You Can’t Lose Weight with Hypothyroidism

  • Writer: Dr. Jessica
    Dr. Jessica
  • 5 days ago
  • 3 min read

thyroid weight loss

If you have been trying to lose weight with hypothyroidism, you might feel like you are doing everything “right” but nothing is happening.


Your clothes feel tight.

Your energy is low.

Your cravings are strong.

You feel puffy or inflamed.


But here is the truth.

It is not your willpower.

It is your physiology.

And, sometimes it's not your thyroid at all that is preventing you from loosing weight.


Hypothyroidism affects far more than your thyroid hormone numbers. It influences metabolism, insulin sensitivity, cholesterol, energy production, and even how your body burns calories at rest.




Why Weight Loss Is Harder with Hypothyroidism


Even mild or early hypothyroidism can slow your metabolic rate. Research shows that low thyroid activity:

  • Reduces calorie burning

  • Slows energy production

  • Raises LDL cholesterol

  • Affects lipid metabolism

  • Increases fatigue


You can be in “normal range” and still feel all of these shifts happening in your body.


Women also notice:

  • More cravings

  • Fluid retention

  • Difficulty building muscle

  • Blood sugar swings

  • Feeling cold

  • Needing more sleep


These changes alone can make weight loss harder, even when you are doing everything you can.




The Real Reason Your Labs Can Look Normal While You Feel Stuck


TSH is a brain signal. It does not show how well your thyroid hormones are being used in the body.


A normal TSH does not guarantee:

  • Adequate T3

  • Good conversion from T4 to T3

  • Healthy cortisol rhythms

  • Stable insulin levels

  • Balanced nutrient stores


This is why women can feel hypothyroid even with “normal” lab ranges.




The Missing Piece: T4 to T3 Conversion

Your thyroid produces mostly T4, a storage hormone. Your body must convert T4 into T3, the active hormone that runs your metabolism.


That conversion can slow down when you have:

  • Stress or high cortisol

  • Inflammation

  • Low iron or ferritin

  • Low selenium

  • Low zinc

  • Illness

  • Calorie restriction

  • Over exercise

  • Poor sleep


When conversion is poor, your T3 becomes low even with normal TSH and T4.T3 is the hormone that controls:

  • Metabolic rate

  • Fat burning

  • Body temperature

  • Energy production

  • Mood

  • Digestion


If T3 is low, your body feels like it is in “energy saving mode.” Weight loss becomes very difficult.




Insulin Resistance and Hypothyroidism: A Common Hidden Link


Hypothyroidism and insulin resistance often show up together. Even subclinical hypothyroidism affects glucose metabolism and lipid markers.


High insulin makes it almost impossible to lose weight because it signals your body to store fat instead of burn it.


Signs of insulin resistance include:

  • Belly weight

  • Intense carb cravings

  • Afternoon crashes

  • Brain fog

  • Irritability when hungry

  • Skin tags

  • Easy weight gain


If insulin resistance is not treated, weight loss will not happen. Insulin promotes fat storage.




Cortisol and Stress Change How Your Thyroid Works


Stress hormones directly affect thyroid hormones. High cortisol can:

  • Slow T4 to T3 conversion

  • Increase reverse T3

  • Disrupt sleep

  • Increase appetite

  • Cause fat storage around the midsection


Women often feel this as:

  • Wired but tired

  • Crashing in the afternoon

  • Waking up at 2 or 3 a.m.

  • A “stress belly” that will not budge


This is not lack of discipline. This is physiology under stress.




Medication Issues That Can Slow Metabolism


You can still struggle with weight even if you are taking thyroid medication. This can happen when:

  • Your dose is too low

  • You are not absorbing it well

  • You take it too close to iron, calcium, or food

  • You need a different form (liquid, gel cap)

  • You convert poorly from T4 to T3


Many women feel better when their treatment takes conversion and absorption into account.




Nutrient Deficiencies That Affect Thyroid and Metabolism


Several nutrients are essential for thyroid hormones and metabolism:

  • Iron, Selenium, Zinc, B12, Vitamin D


If these are low, weight loss becomes harder because your metabolism is working with less fuel.




The Emotional Side: It’s Not Laziness. It’s Biology.


Many women with thyroid issues blame themselves. They tell themselves they are not trying hard enough.

They wonder what is wrong with them.

Nothing is wrong with you.

Your biology is doing exactly what the body does when it senses low thyroid activity or stress.


It protects you.

It slows you down.

It stores energy.

You are not failing. Your physiology is adapting.



The Plan I Use for Women Who Feel Stuck

Every plan is individualized, but most women need support in four main areas:


2. Improve thyroid hormone activation & conversion

3. Screening & treatment for insulin resistance

4. Support stress and cortisol patterns


Weight loss becomes possible again when the root issues are treated, not when women push harder.



If this feels like you

You are not alone, and you are not imagining your symptoms.


If you want support and clear next steps, you can book a free ten-minute discovery call.


We will go through your symptoms, I will describe my process and how I can help you. We will see if it's a good fit to work together!



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Dr. Jessica Nesbitt ND

Naturopathic Doctor – Virtual Practice Serving All of Ontario

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Helping women across Ontario uncover hidden hormone and nutrient imbalances through virtual naturopathic care, advanced testing, and individualized support.

The material provided on this website is for information purposes only.

© 2025 Dr. Jessica Nesbitt ND 

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